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Table 1 Summary of ordered subset linkage analysis

From: A genome-wide ordered-subset linkage analysis for rheumatoid arthritis

   

Max

No. families

Covariate range

  

Covariates

Chr. no.

Linkage peak (cM)a

Newb

Oldc

Deltad

p-Value (Delta Max)e

With defined covariate values

In best ordered subsetf

Bestg

Totalh

p-Value (Permutations)

95% CI

Age of onset

4

102.03

4.45

3.55

0.9

0.012

606

+472

[31.5–83.0]

[11.0–83.0]

0.021

[0.0078, 0.0194]

 

9

0.59

2.85

1.18

1.67

0.022

606

+27

[59.5–83.0]

[11.0–83.0]

0.022

[0.0141, 0.0349]

Anti-CCP level

2

154.17

3.72

2.83

0.9

0.048

590

+219

[133–413]

[0.8–413]

-0.951

[0.0302, 0.0742]

 

18

26.29

3.73

2.46

1.27

0.022

590

+40

[234–413]

[0.8–413]

0.022

[0.0138, 0.0342]

 

19

52.22

3.27

1.01

2.26

0.009

590

-10

[0.8–3.50]

[0.8–413]

0.009

[0.0057, 0.0142]

  1. a Location of maximum score, maximized over all ordered subsets.
  2. b Maximum score, maximized over all loci and ordered subsets.
  3. c Maximum score using all families with a covariate value, maximized over all loci.
  4. d Delta Max = (New Max) - (Old Max)
  5. e Probability of observing a change in LOD score greater than or equal to delta max if family linkage scores and family covariate scores are independent.
  6. f + or -, the best ordered subset consists of families with the highest (+) or lowest (-) covariate scores.
  7. g Range of covariate values in the ordered subset with highest linkage score.
  8. h Range of covariate scores in the set of all families.