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Table 2 Sensitivity and specificity of three SNPs associations with two different phenotypes (50 replications)

From: Rheumatoid arthritis, item response theory, Blom transformation, and mixed models

 

Sensitivity (%)

Specificity (%)

Traits(s) transformation

SNP1a

SNP2&3b

SNP1-3

GENE1c

GENE2

SNP1

SNP2&3

SNP1-3

GENE1

GENE2

IRT latent variable

24.00

7.00

12.70

7.30

4.80

94.79

94.79

94.79

94.80

94.78

Anti-CCP Blom transformation

100.00

6.00

37.30

46.20

10.10

93.21

93.20

93.21

93.42

93.21

  1. aSNP1 is located at 32,484,648 bp and labeled as m3437.
  2. bSNP2&3 flank the location 37,233,784 bp and labeled as m3916 and m3917.
  3. cGENE1 and GENE2 represent, respectively, a region ~500 kb around SNP1 (assumed as locus DR) and around SNP2 and SNP3 (Locus D).