From: Meta-genetic association of rheumatoid arthritis and PTPN22using PedGenie 2.1
 | PedGenie 2.1 |  | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | NARAC Study 1a | NARAC Study 2b | Meta-analysis | Previously publishedc,d | ||||||||||
PTPN22 | MAFe | OR | 95% CI | p f | MAFe | OR | 95% CI | p f | OR | 95% CI | p g | OR | 95% CI | p h |
Rs3789604 | 0.182 | 1.11 | 0.88–1.41 | 0.36 | 0.175 | 1.15 | 0.95–1.39 | 0.17 | 1.13 | 0.98–1.32 | 0.10 | 1.15 | 0.97–1.35 | 0.11 |
Rs3811021 | 0.182 | 1.11 | 0.88–1.40 | 0.38 | 0.176 | 1.14 | 0.95–1.37 | 0.17 | 1.13 | 0.97–1.31 | 0.11 | 1.15 | 0.97–1.36 | 0.10 |
rs1217413 | 0.210 | 1.38 | 1.13–1.70 | 0.003 | 0.230 | 1.28 | 1.07–1.53 | 0.002 | 1.32 | 1.16–1.51 | <0.001 | 1.37 | 1.18–1.60 | <0.001 |
ss38346942 | 0.015 | 1.21 | 0.61–2.37 | 0.59 | 0.012 | 1.22 | 0.65–2.27 | 0.56 | 1.21 | 0.75–1.97 | 0.42 | 1.03 | 0.59–1.79 | 1.00 |
rs1217388 | 0.246 | 1.29 | 1.04–1.59 | 0.017 | 0.260 | 1.20 | 1.01–1.42 | 0.028 | 1.23 | 1.07–1.42 | 0.003 | 1.28 | 1.11–1.49 | 0.001 |
ss38346943 | 0.031 | 0.32 | 0.16–0.67 | 0.001 | 0.023 | 0.84 | 0.47–1.48 | 0.55 | 0.60 | 0.39–0.92 | 0.020 | 0.63 | 0.40–1.01 | 0.05 |
rs1310182 | 0.430 | 1.28 | 1.06–1.56 | 0.008 | 0.435 | 1.28 | 1.09–1.49 | 0.001 | 1.28 | 1.13–1.45 | <0.001 | 1.35 | 1.18–1.54 | <0.001 |
ss38346944 | 0.029 | 1.14 | 0.65–1.99 | 0.63 | 0.019 | 1.37 | 0.84–2.22 | 0.24 | 1.26 | 0.85–1.85 | 0.24 | 1.29 | 0.87–1.93 | 0.21 |
rs2476601 | 0.087 | 1.79 | 1.39–2.30 | <0.001 | 0.085 | 2.19 | 1.75–2.74 | <0.001 | 2.03 | 1.70–2.42 | <0.001 | 1.93 | 1.58–2.37 | <0.001 |
(R620W) |  |  |  |  |  |  |  |  |  |  |  | 2.184 | 1.76–2.70 | <0.001 |
rs12730735 | 0.292 | 0.83 | 0.68–1.01 | 0.07 | 0.295 | 0.89 | 0.76–1.04 | 0.14 | 0.86 | 0.76–0.98 | 0.025 | 0.81 | 0.70–0.94 | 0.006 |
rs11102685 | 0.076 | 1.21 | 0.87–1.77 | 0.26 | 0.078 | 1.20 | 0.93–1.55 | 0.19 | 1.20 | 0.98–1.49 | 0.09 | 1.27 | 1.01–1.60 | 0.040 |
rs12760457 | 0.291 | 0.83 | 0.68–1.02 | 0.09 | 0.296 | 0.88 | 0.74–1.05 | 0.14 | 0.86 | 0.76–0.98 | 0.022 | 0.82 | 0.71–0.96 | 0.010 |
rs2488458 | 0.246 | 1.29 | 1.05–1.58 | 0.014 | 0.260 | 1.20 | 1.01–1.41 | 0.037 | 1.23 | 1.08–1.41 | 0.003 | 1.27 | 1.10–1.48 | 0.002 |
rs1217414 | 0.282 | 0.88 | 0.70–1.10 | 0.20 | 0.270 | 0.84 | 0.72–0.99 | 0.06 | 0.86 | 0.76–0.97 | 0.018 | 0.84 | 0.72–0.98 | 0.020 |