From: Meta-genetic association of rheumatoid arthritis and PTPN22using PedGenie 2.1
 |  | PedGenie 2.1 |  |  |  | ||||||||
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 |  | NARAC Study 1a | NARAC Study 2b | Meta-analysis | Previously publishedc | ||||||||
RA Phenotype | Genotype | OR | 95% CI | p d | OR | 95% CI | p d | OR | 95% CI | p e | OR | 95% CI | p |
RF+ vs. Ctrls. | CT or TT | 1.80 | 1.29–2.49 | <0.001 | 2.34 | 1.82–3.00 | <0.001 | 2.13 | 1.76–2.57 | <0.001 | 2.36 | 1.76–3.16 | <0.001 |
RF- vs. Ctrls. | CT or TT | 1.40 | 0.87–2.27 | 0.20 | 1.08 | 0.71–1.65 | 0.77 | 1.20 | 0.87–1.65 | 0.31 | 1.17 | 0.6–2.31 | 0.64 |
RF+ vs. RF- | CT or TT | 1.07 | 0.58–2.00 | 0.79 | 1.46 | 0.83–2.56 | 0.12 | 1.30 | 0.86–1.95 | 0.18 |  |  |  |
 |  |  |  |  |  |  |  |  |  |  | Previously publishedf | ||
CCP+ vs. Ctrls. | CT or TT | 1.69 | 1.18–2.41 | 0.001 | 2.03 | 1.57–2.62 | <0.001 | 1.90 | 1.55–2.34 | <0.001 | 1.49 | 1.23–1.79 | <0.001 |
CCP- vs. Ctrls. | CT or TT | 1.59 | 1.04–2.45 | 0.035 | 1.41 | 1.03–1.95 | 0.029 | 1.47 | 1.15–1.88 | 0.001 | 1.04 | 0.83–1.29 | 0.40 |
CCP+ vs. CCP- | CT or TT | 1.05 | 0.61–1.80 | 0.93 | 1.16 | 0.83–1.60 | 0.32 | 1.12 | 0.84–1.50 | 0.47 |  |  |  |
RF or CCP+ vs. RF-/CCP- | CT or TT | 1.29 | 0.65–2.53 | 0.55 | 1.43 | 0.81–2.52 | 0.06 | 1.38 | 0.89–2.13 | 0.051 | 1.43 | 1.16–1.77 | <0.001 |