Table 1 Principal components of heritability and linkage analysis
| Â | Principal components analysis | Linkage analysis | ||||||
|---|---|---|---|---|---|---|---|---|
First 3 components in each cluster | Clustering method | Cluster | No. members | Cumulative % variation explained | Genome-wide peak t-value | Genome-wide peak p-value | SNP | Peak location |
A.1 | Classical | A | 10 | 36% | 3.7 | 1.25 × 10-4 | rs1333050 | chr 9 (43.9 cM) |
A.2 | Classical | A | 10 | 58% | 3.01 | 1.00 × 10-3 | rs983795 | chr 14 (77.3 cM) |
A.3 | Classical | A | 10 | 72% | 3.59 | 1.90 × 10-4 | rs332364 | chr 3 (93.3 cM) |
B.1 | Proposed | B | 8 | 37% | 4.31 | 1.06 × 10-5 | rs941838 | chr 14 (113 cM) |
B.2 | Proposed | B | 8 | 62% | 4.82 | 1.02 × 10-6 | rs1955897 | chr 14 (110.5 cM) |
B.3 | Proposed | B | 8 | 77% | 4.06 | 2.93 × 10-5 | rs297675 | chr 20 (11.9 cM) |
C.1 | Proposed | C | 11 | 41% | 4.46 | 5.31 × 10-6 | rs1892302 | chr 10 (27 cM) |
C.2 | Proposed | C | 11 | 58% | 4.99 | 4.62 × 10-7 | rs2206185 | chr 6 (111.2 cM) |
C.3 | Proposed | C | 11 | 68% | 5.36 | 7.35 × 10-8 | rs1950475 | chr 14 (109 cM) |
D.1 | Proposed | D | 10 | 38% | 4.61 | 2.78 × 10-6 | rs1950475 | chr 14 (109.6 cM) |
D.2 | Proposed | D | 10 | 60% | 3.32 | 4.95 × 10-4 | rs739495 | chr 19 (58.5 cM) |
D.3 | Proposed | D | 10 | 74% | 3.34 | 4.62 × 10-4 | rs1955897 | chr 14 (110.5 cM) |