A two-step multiple-marker strategy for genome-wide association studies

BMC Proceedings

Table 1 Results for the first 10 regions in the first replicates

	Step 1				Step 2
Region	Chr	IDs of the 2 extreme markers bounding a region		Local Scores^a	FBAT_LC p-value^b	Bonferroni corrected p-value	Trait loci in the region
1	6	128	162	8235.4874	0.000000	0.000000	DR, C, D
2	11	387	396	202.3407	0.000000	0.000000	F
3	18	269	269	44.5575	0.000000	0.000000	E
4	18	10	11	28.2714	0.042545	0.425450
5	10	355	357	16.8203	0.476407	1.000000
6	4	347	348	11.7416	0.440749	1.000000
7	6	355	355	11.6840	0.002913	0.029130
8	3	58	58	11.5742	0.137617	1.000000
9	8	392	392	11.5131	0.387798	1.000000
10	7	94	95	11.4852	0.706698	1.000000

^aLocal Scores obtained from the first replicate of case-control data.
^bp-Values obtained from FBAT-LC applied to regions selected in Step 1 in the first replicate of family data.

ISSN: 1753-6561