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Table 3 Performance of the multiple-marker strategy in disease severity analysis

From: A two-step multiple-marker strategy for genome-wide association studies

Correction for multiple testing

FBAT LC

% of severity loci detectedb

 

Sensitivitya

Specificitya

FDRa

 

Without correction

1.00 (0.00)

0.92 (0.03)

0.75 (0.13)

0.91 (0.19)

Benjamini & Hochberg

0.96 (0.20)

0.99 (0.01)

0.14 (0.24)

0.87 (0.26)

Bonferroni

0.96 (0.20)

0.99 (0.01)

0.14 (0.24)

0.87 (0.26)

  1. aMean (standard deviation) of sensitivity, specificity and false-discovery rate of FBAT-LC test computed over 50 replicates of family data when 50 regions were selected in Step 1.
  2. bMean (standard deviation) of the proportion of severity loci selected in Step 1 and detected in Step 2 by FBAT at the 5% level over 50 replicates when 50 regions were selected in Step 1.