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Table 4 Problem 1 empirical power computed under the polygenic trait model power with varying heritability and proportion of genetic variance due to polygenes (t)

From: One-stage design is empirically more powerful than two-stage design for family-based genome-wide association studies

 

Powera

 

t = 0.2

t = 0.5

 

h2 = 0.5

h2 = 0.8

h2 = 0.5

h2 = 0.8

2-stage (n = 10)

0.58

0.83

0.15

0.26

1-stage CLRT (n = 1509)

0.99

1

0.73

0.97

  1. aNominal type I error rate of α = 0.05, using a Bonferroni correction
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BMC Proceedings

ISSN: 1753-6561

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