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Table 2 Penetrance and coupling associated with PTPN22 rs2476601

From: Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis

Genotype

Co-dominant

Dominant model

Recessive model

Penetrancea

   

   TT

1

1

1

   TC

0.54 [0.42–0.75]

1

0.17 [0.13–0.22]

   CC

0.20 [0.12–0.30]

0.20 [0.14–0.28]

0.17 [0.13–0.22]

Coupling

   

   T

0.99 [0.54–1]

0.27 [0.15–0.43]

0.99 [0.96–1]

   C

0.07 [0–0.13]

0.01 [0–0.02]

0.22 [0.19–0.28]

-2*log likelihood

-2066.63

-2073.72

-2093.58

p-value

0.20

0.02

1.5 × 10-5

  1. aThe reference genotype is TT