Statistical corrections of linkage data suggest predominantly cis regulations of gene expression

BMC Proceedings

Table 1 Significant results in the uncorrected, corrected, and cis-only analyses

	Number of genes with a significant linkage signal
Analysis	cis	trans	cis and trans	Multiple trans	Total
Uncorrected^a	27	110	2	3	142
Corrected^b	19^c	3	0	0	22
Corrected (cis only)^d	46	--	--	--	46

^aUncorrected analysis of Morley et al. [1]
^bCorrected method described in this paper
^cThe 19 cis signals in the corrected analysis are a subset of the 27 in the uncorrected analysis, which are a subset of the 46 in the cis-only analysis.
^dCorrected method when only the 10-Mb region around each gene is considered (and thus the correction for multiple tests is less severe).

ISSN: 1753-6561