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Table 1 Number of expressions with at least one significant eQTL

From: Controlling for false positive findings of trans-hubs in expression quantitative trait loci mapping

 

Genome-wide significance level (point-wise significance level)

 

0.05 (4.7 × 10-6)

0.01 (3.2 × 10-7)

0.001 (6.7 × 10-9)

Threshold by Gaussian approximation

4.43

4.98

5.68

Number by chance (95% CI)

177.7 (162.2, 193.2)

35.6 (28.5, 42.6)

3.6 (1.3, 5.8)

Original data

   Threshold by permutation

4.36

4.95

5.68

   Number by permutation (95% CI)

176.0 (139.0, 224.5)

36.0 (24.0, 56.0)

4.0 (0, 9.0)

   Observed number

235

66

24

   Sibship only

173

40

13

Residual data (9p13.3)

   Threshold by permutation

4.45

5.06

5.81

   Number by permutation (95% CI)

180.0 (154.0, 207.0)

36.0 (25.0, 48.0)

4.0 (0, 8.0)

   Observed number

225

87

26

Residual data (14q32)

   Threshold by permutation

4.46

5.07

5.85

   Number by permutation (95% CI)

178.0 (151.5, 205.0)

36.0 (24.0, 47.0)

3 (0, 8.0)

   Observed number

212

70

23