From: Controlling for false positive findings of trans-hubs in expression quantitative trait loci mapping
 | Genome-wide significance level (point-wise significance level) | ||
---|---|---|---|
 | 0.05 (4.7 × 10-6) | 0.01 (3.2 × 10-7) | 0.001 (6.7 × 10-9) |
Threshold by Gaussian approximation | 4.43 | 4.98 | 5.68 |
Number by chance (95% CI) | 177.7 (162.2, 193.2) | 35.6 (28.5, 42.6) | 3.6 (1.3, 5.8) |
Original data | |||
   Threshold by permutation | 4.36 | 4.95 | 5.68 |
   Number by permutation (95% CI) | 176.0 (139.0, 224.5) | 36.0 (24.0, 56.0) | 4.0 (0, 9.0) |
   Observed number | 235 | 66 | 24 |
   Sibship only | 173 | 40 | 13 |
Residual data (9p13.3) | |||
   Threshold by permutation | 4.45 | 5.06 | 5.81 |
   Number by permutation (95% CI) | 180.0 (154.0, 207.0) | 36.0 (25.0, 48.0) | 4.0 (0, 8.0) |
   Observed number | 225 | 87 | 26 |
Residual data (14q32) | |||
   Threshold by permutation | 4.46 | 5.07 | 5.85 |
   Number by permutation (95% CI) | 178.0 (151.5, 205.0) | 36.0 (24.0, 47.0) | 3 (0, 8.0) |
   Observed number | 212 | 70 | 23 |