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Table 1 Association between SNPs and RA

From: Evaluating gene × gene and gene × smoking interaction in rheumatoid arthritis using candidate genes in GAW15

Candidate gene

SNP

p-value (11 vs. 12 vs. 22)

p-value (11/12 vs. 22)

HAVCRI

5509_5511delCAA

0.066

0.034 a

HAVCRI

rs6149307

0.189

0.068

CTLA4

CT60

0.016

0.005

CARD15

HugotSNP12ms3

--b

0.754

CARD15

HugotSNP8ms2

0.838

0.553

CARD15

Hugot_SNP13ms2

--

0.695

Chr 5

IGR2096ms1

0.473

0.243

Chr 5

IGR3084ms1

0.819

0.713

Chr 5

IGR3138ms1

0.861

0.732

IL3

rs31480

0.618

0.384

SUMO4

rs237025

0.0003

<0.0001

MAP3K7IP2

rs577001

0.002

0.001

MIF

rs755622

0.842

0.979

TNFRFF1b

rs1061622

0.704

0.684

DLG5

rs1248696

0.269

0.129

SLC22A4

rs2073838

0.904

0.771

PADI4

rs2240340

0.574

0.330

IL4

rs2243250

0.311

0.147

RUNX1

rs2268277

0.55

0.583

PTPN22

rs2476601

<0.0001

<0.0001

  1. Allele "1" is the putative susceptibility allele, and allele "2" is the non-susceptibility allele
  2. aBold text indicates p < 0.05.
  3. b--, Results are not available because there is no homozygote "11" in some groups.