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Table 3 Single-SNP case-control analysis for SNPs in 14 candidate genes

From: Case-control association analysis of rheumatoid arthritis with candidate genes using related cases

  

Minor Allele Frequencies

p-valuesa

  

Cases

Controls

  

Gene

dbSNP ID

Affected Siblingb (n = 816)

One Sibling per Familyc (n = 461)

(n = 855)

Affected Siblingb

One Sibling per Familyc

PTPN22

Rs2476601

0.163

0.156

0.084

2.13 × 10-10

4.96 × 10-8

CTLA4

Rs3087243

0.447

0.407

0.447

0.01016

0.04618

HAVCR1

Rs6149307

0.17

0.174

0.142

0.03939

0.03193

HAVCR1

5509_5511 delCAA

0.195

0.200

0.235

0.01834

0.05172

SUMO4

Rs237025

0.517

0.520

0.456

0.00154

0.00202

SUMO4

Rs577001

0.391

0.387

0.350

0.02512

0.06162

  1. ap-Values were not adjusted for the multiple testing. Only significant results are presented in the table.
  2. bAllele frequencies and p-values were obtained using all cases and unrelated controls.
  3. cAllele frequencies and p-values were obtained using one randomly selected case per family and unrelated controls.