Table 2 A list of GO molecular function categories highly significantly (p ≤ 0.01) enriched with genes of high familial aggregations
GO ID | GO Description | n a | m b | p |
|---|---|---|---|---|
GO:0000166 | nucleotide binding | 468 | 202 | 6.15 × 10-7 |
GO:0003735 | structural constituent of ribosome | 54 | 5 | 2.5 × 10-5 |
GO:0003723 | RNA binding | 177 | 83 | 4.64 × 10-5 |
GO:0004872 | receptor activity | 174 | 37 | 9.95 × 10-5 |
GO:0005509 | calcium ion binding | 150 | 31 | 0.000154 |
GO:0051082 | unfolded protein binding | 66 | 36 | 0.000187 |
GO:0005524 | ATP binding | 377 | 152 | 0.000578 |
GO:0005515 | protein binding | 880 | 264 | 0.001239 |
GO:0004004 | ATP-dependent RNA helicase activity | 6 | 6 | 0.001397 |
GO:0016874 | ligase activity | 73 | 35 | 0.003392 |
GO:0003779 | actin binding | 57 | 10 | 0.003461 |
GO:0003700 | transcription factor activity | 232 | 63 | 0.005974 |
GO:0004842 | ubiquitin-protein ligase activity | 31 | 17 | 0.007186 |
GO:0003676 | nucleic acid binding | 80 | 36 | 0.008773 |
GO:0005506 | iron ion binding | 57 | 27 | 0.009803 |