Table 1 Median and interquartile range of variable rankings and importance measures on simulated interacting risk factors
GBM | MCLR | RF | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median ranking | Ranking interquartile range | Median importance | Importance interquartile range | Median ranking | Ranking interquartile range | Median importancea | Importance interquartile rangea | Median ranking | Ranking interquartile range | Median importance | Importance interquartile range | |
Chromosome 6, SNP A, Dominant | 1 | No variation | 43.18 | 43.08–43.27 | 4 | 3–4 | 1 | No variation | 2 | 2–3 | 110.5 | 106.8–113.4 |
Chromosome 6, SNP A, Recessive | 3 | No variation | 9.23 | 9.20–9.25 | 3 | 2–3 | 1 | No variation | 4 | No variation | 55 | 53.0–57.1 |
Chromosome 6, SNP B, Dominant | 2 | No variation | 39.02 | 38.94–39.14 | 5 | 4–5 | 1 | No variation | 3 | 2–3 | 108 | 105.1–110.4 |
Chromosome 6, SNP B, Recessive | -- b | -- | -- | -- | 256 | 217–300 | 0.0009628 | 0.0008214–0.001118 | 6 | No variation | 23.4 | 22.5–24.4 |
Chromosome 8, Disease Locus, Dominant | 13 | 12–13 | 0.07 | 0.065–0.075 | 7 | 6–7 | 0.9998 | 0.9921–1 | 14 | No variation | 2.6 | 2.5–2.6 |
Chromosome 8, Disease Locus, Recessive | -- | -- | -- | -- | 21 | 11–44 | 0.0105 | 0.003999–0.428 | 1322 | 1079–1533 | 0.57 | 0.53–0.61 |
Chromosome 16, Disease Locus, Dominant | -- | -- | -- | -- | 624 | 525–716 | 0.0004029 | 0.0003219–0.0004992 | 51 | 40–75 | 0.85 | 0.81–0.91 |
Chromosome 16, Disease Locus, Recessive | 11 | No variation | 0.087 | 0.083–0.093 | 2027 | 1757–2305 | 0.0000826 | 5.63e-5-0.0001214 | 31 | 29–32 | 1.05 | 1.01–0.12 |
Sex | 5 | No variation | 1.975 | 1.96–1.99 | 2 | 2–6 | 0.9998 | 0.9921–1 | 8 | No variation | 11.8 | 11.6–12.4 |
Smoking | 4 | No variation | 2.35 | 2.34–2.36 | 20 | 10–43 | 0.0105 | 0.003999–0.428 | 10 | No variation | 6.8 | 6.6–7.1 |