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Table 4 Power of the haplotype-trait association test using 500 case-control pairs

From: Comparison of the power of haplotype-based versus single- and multilocus association methods for gene × environment (gene × sex) interactions and application to gene × smoking and gene × sex interactions in rheumatoid arthritis

Common haplotypesa

Frequencyb

Model 1c (main effects of haplotypes)

Model 2c (main effects and haplotype-sex interaction effects)

   

Main

Interaction

21221111121 22221211221

0.06

1

0.95

0.78

1111111111 3 1 1111111211

0.07

0.99

0.82

0.66

21221111121 22221211121

0.11

1

0.99

0.65

1111111111 3 1 1111111111 (reference haplotype)

0.39

   
  1. a Haplotypes present in at least 80 replicates of the 100 replicates (risk loci are underlined, DR locus italicized, C locus not italicized), including the alleles at the 22 loci
  2. b Estimated haplotype frequencies (combined sample) in the 100 replicates
  3. c Power is the percentage of replicates in which the main or interaction effect of the respective haplotype had an adjusted p-value of ≤ 0.05.