The role of heritability in mapping expression quantitative trait loci

BMC Proceedings

Table 1 Linkage analysis with all 14 pedigrees

Genes^a	cis or trans	h ^2b	Reg^c	VC^d	p-value^e
OR6A2	trans	0	5.83	0.31	0.027
NDUFB4	trans	0	7.05	0.59	0.038
MAP3K6	trans	0	7.39	1.39	0.004
RGS1	trans	0	7.66	0.85	0.014
ARPC5L	cis	0	8.91	1.12	0.015
CHI3L2	cis	0.75	15.10	12.97	0.001
ITGB1BP1	cis	0.66	11.05	8.35	0.001
HLA-DPB1	cis	0.70	14.62	8.53	0.001
HLA-DQB1	cis	0.86	16.16	14.52	0.001
ZP3	cis	0.87	20.86	14.37	0.001

^aFrom the 23 genes with heritability estimates equal to 0, five genes with the highest MERLIN-REGRESS LOD scores are shown in the top five rows; from 422 genes with significant MERLIN-REGRESS LOD scores, five genes with the highest heritability estimates are shown on the bottom five rows as a comparison.
^b The trait heritability estimations.
^c The genome-wide maximum LOD scores obtained from MERLIN-REGRESS method.
^d The genome-wide maximum LOD scores obtained from MERLIN variance component method.
^ep-value from the permutation procedures.

ISSN: 1753-6561