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Anti-epileptic properties of oleamide

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Epilepsy is a heterogeneous group of disorders. It is the most common neurological disorder after the stroke, with a 2–3% life-time risk of being given a diagnosis of epilepsy [1]. Antiepileptogenic drugs that retard or prevent epileptogenesis are not yet available [2]. Extract of the plant Aquilegia vulgaris is widely used in folk medicine as an antiepileptic medicament [3]. We have previously demonstrated that oleamid – sleep inducing lipid and myo-inositol are two compounds acting on γ-aminobuturic acid type A receptors and hence candidates determining the anti-epileptic properties of the plant Aquilegia vulgaris [4]. Further it was shown that myo-inositol reduces the strength of seizures induced either by pentylentetrazol or kainic acid in rats. In the present work we are demonstrating that oleamid also posseses anti-epileptic features and significantly decreases the degrees of convulsions induced by pentylentetrazole in rats.

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    Loscher W: Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Research. 2002, 50: 105-123. 10.1016/S0920-1211(02)00073-6.

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    Shreter AI: Medicinal Herbs of Soviet Far East. 1975, Moscow: Medicina, 105-106.

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    Solomonia R, Kuchiashvili N, Berulava A, Pkhakadze V, Trapaidze N, Zhvania M, Abesadze I, Kojima H, Dalakishvili N: Purification and identification of components of the Aquilegia vulgaris extract fraction exhibiting anti-epileptic activity. J Biol Phys Chem. 2004, 4: 187-192.

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Correspondence to Ekaterine Mikautadze.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mikautadze, E., Avaliani, N., Kuchiashvili, N. et al. Anti-epileptic properties of oleamide. BMC Proc 2, P42 (2008) doi:10.1186/1753-6561-2-s1-p42

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Keywords

  • Public Health
  • Lipid
  • Neurological Disorder
  • Heterogeneous Group
  • Folk Medicine