Detection of imprinting and heterogeneous maternal effects on high blood pressure using Framingham Heart Study data

Table 1 Parameter estimates and p-values of the fixed effect model in the first step

Location	SNP	Association with BP	and p-value		and p-value		and p-value		and p-value		and p-value
Chr2 p22.3	rs1979148	Rat	0.406	0.3365	-3.579	0.2899	-1.445	0.0200	1.648	0.0000	1.769	0.0517
Chr1 q41	rs17476063	Rat	0.661	0.0883	-0.650	0.3358	-2.201	0.0015	1.644	0.0000	0.441	0.7048
Chr4 q26	rs1459543	Human	1.957	0.0000 ^a	1.296	0.0146	-1.586	0.0109	0.346	0.3935	0.100	0.8677
Chr1 p36.22	rs6688233	Human, Rat	1.573	0.0000	0.234	0.7368	-1.609	0.0112	0.377	0.3854	0.747	0.3410
Chr6 q24.1	rs4386830	Human	1.046	0.0178	-1.018	0.0809	-2.414	0.0003	1.741	0.0001	3.031	0.0000
Chr3 p14.1	rs13076104	Rat	1.323	0.0000	-0.008	0.9910	-1.154	0.0820	0.141	0.7209	0.487	0.5428
Chr2 q24.1	rs10209732	Human, Rat	0.469	0.3301	-1.535	0.1515	-1.089	0.1160	1.632	0.0000	1.746	0.0619
Chr3 q26.1	rs2030350	Human, Rat	-0.260	0.5752	-0.902	0.1503	-1.856	0.0202	1.422	0.0000	0.726	0.5396
Chr3 p12.1	rs9866277	Rat	1.442	0.0000	0.100	0.9367	-0.488	0.5423	-0.565	0.3501	-0.361	0.7332

^aBold font under , , , and indicates p-value ≤ 0.05. Bold font under indicates p-value ≤ 0.05 and at least one p-value ≤ 0.05 for testing whether β₁ = 0 and β₂ = 0

ISSN: 1753-6561