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Table 1 Forward-stepwise selection in NARAC data with 27 GO biological processes

From: Integration of gene ontology pathways with North American Rheumatoid Arthritis Consortium genome-wide association data via linear modeling

     

Pathway effect estimates for consecutive models obtained when adding terms as shown in column 1

Modela

Deviance

AIC

b

       

Selected Model

   

Intercept

 

-65279.5

0.001916

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.16

0.16

+GO:0009605 c

4.27

-65285.99

0.001915

 

0.017

0.017

0.017

0.018

0.018

0.017

0.017

0.018

0.021

0.022

0.018

+GO:0006996

2.29

-65288.57

0.001913

  

-0.010

-0.010

-0.014

-0.014

-0.015

-0.015

-0.015

-0.014

-0.014

-0.014

+GO:0006968

1.75

-65290.08

0.001911

   

-0.025

-0.025

-0.024

-0.024

-0.024

-0.024

-0.024

-0.024

-0.034

+GO:0030036

1.62

-65291.31

0.001909

    

0.020

0.035

0.035

0.035

0.035

0.035

0.035

0.035

+GO:0007015

3.07

-65295.45

0.001907

     

-0.055

-0.055

-0.055

-0.055

-0.055

-0.055

-0.055

+GO:0006508

1.53

-65296.50

0.001904

      

0.013

0.013

0.013

0.013

0.013

0.013

+GO:0009100

0.99

-65296.47

0.001904

       

0.016

0.017

0.017

0.017

0.017

+GO:0006629

1.07

-65296.61

0.001903

        

-0.008

-0.008

-0.008

-0.008

+GO:0006950

0.46

-65295.54

0.001902

         

-0.005

-0.005

-0.007

+GO:0009617

0.49

-65294.52

0.001902

          

-0.019

-0.007

+GO:0006952

0.85

-65294.23

0.001902

           

0.012

  1. aGO definitions: GO:0009605, response to external stimulus; GO:0006996, organelle organization and biogenesis; GO:0006968, cellular defense response; GO:0030036, actin cytoskeleton organization and biogenesis GO:0007015, actin filament organization; GO:0006508, proteolysis; GO:0009100, glycoprotein metabolic process; GO:0006629, lipid metabolic process.
  2. b , the between-gene variance estimate
  3. c Bold font indicates elements included in the selected model.