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Volume 6 Supplement 3

Metabolism, diet and disease

  • Poster presentation
  • Open Access

Cellular metabolic response to DNA damage

  • 1 and
  • 1
BMC Proceedings20126 (Suppl 3) :P24

https://doi.org/10.1186/1753-6561-6-S3-P24

  • Published:

Keywords

  • Glutamine
  • Cell Cycle Arrest
  • Metabolic Response
  • Cellular Metabolism
  • Cellular Signaling

DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. The metabolic response to DNA damage is largely unknown. Here we report a novel metabolic response to genotoxic stress. DNA damage triggers a critical block in the uptake of glutamine, a mitochondrial substrate essential for cellular proliferation. Sirtuins regulate both cellular metabolism and stress responses. We found mitochondrial SIRT4 is involved in the metabolic response to DNA damage. These results suggest that the metabolic adaptation is important for cellular DNA damage response.

Authors’ Affiliations

(1)
Department of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA, USA

Copyright

© Jeong and Haigis; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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