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Fig. 1 (abstract P-225). | BMC Proceedings

Fig. 1 (abstract P-225).

From: Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

Fig. 1 (abstract P-225).

a One hallmark of MVA-CR19 is a significantly reduced tendency to induce syncytia and an increased dispersion of plaques in CR.pIX cell monolayers. This property appears to be supported by the mutation in A34R. b Electron microscopy reveals no obvious differences between novel genotype and wildtype. The top panels show intracellular infectious viruses, the bottom panels immature virions in the process of genome packaging. The scale bar in (b) is 1 μm wide, experiments in (a) and (b) werde done with recombinant viruses that express GFP. c The right telomere of the virus, starting with bp 150816, has been found to have recombined with the left telomere at bp 15322 (using numbering of GenBank sequence U94848). Top panel in (c) is a diagram of the full wildtype genome, center panel enlarges the telomeres of the wildtype, and bottom panel highlights the left telomere of MAV-CR19 together with the recombination site. ITR, inverted terminal repeat; roman numerals for amplicons that confirm deletion sites in MVA, open arrows for genes loacated in the telomeres

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