Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits

Table 1 Distribution of selected clinical characteristics among study participants from rheumatoid arthritis studies for GAW15 Problem 2

Study source	US Micros^a	US-SNPs^b	Canada Affymetrix	Canada Illumina^c	France	UK Cohort 1^d	UK Cohort 2^e
Ascertainment criteria	2 ACR+ sibs, 1 with erosions	2 ACR+ sibs, 1 with erosions	2 ACR+ sibs		2 ACR+ sibs	2 ACR+ sibs	2 ACR+ sibs
Number of families	511	757	79	60	88	174	195
Affected sibs/family	2.13	2.15	2	2	2.18	2.13	2.09
% SE+	71%	79%	N/A	N/A	N/A	90%	82%
% Erosion	95%	97%	39%	N/A	N/A	76%	71%
Median age onset	39.1	38.9	43.8	N/A	N/A	39.3	44.0
% RF+	81.1%	74.3%	71.1%	N/A	N/A	62.5%	56.7%

^aNumbers from Jawaheer et al. [17]. One family was eliminated from GAW15 data because one sib did not meet ACR criteria for RA.
^bOf these families, 9 had only phenotype information and no SNP genotypes, 509 families have both SNP and microsatellite data, 2 families have microsatellite data only, and 237 have SNP data only.
^c47 families have genotype data using both Affymetrix and Illumina platforms.
^d174 affected families had microsatellite data and of these 157 also had SNP genotyping.
^eSelected microsatellite markers were genotyped for variable numbers of these families.

ISSN: 1753-6561