Association of KCNB1 to rheumatoid arthritis via interaction with HLA-DRB1

BMC Proceedings

Table 1 p-Values in three association tests based on 10,000 permutations

SNP	ID	Position	function	Interaction effect	Both effects	Proposed model
1	rsl051295	47,422,312	3'UTR	0.0008	0.0018	0.0008
2	rs2426154	47,435,402	intron	0.0011	0.0017	0.0008
3	rs237485	47,437,645	intron	0.0008	0.0015	0.0008
4	rs1961192	47,439,714	intron	0.0004	0.0005	0.0003
5	rs9636516	47,440,607	intron	0.0007	0.0017	0.0012
6	rs6063397	47,449,616	intron	0.0011	0.0023	0.0008
7	rs2057077	47,457,043	intron	0.0011	0.0017	0.0005
8	rs6067085	47,458,509	intron	0.0001	0.0011	0.0004
9	rs6090975	47,459,969	intron	<0.0001	<0.0001	<0.0001
10	rs6125647	47,460,870	intron	0.0003	0.0004	<0.0001
11	rs926673	47,463,417	intron	<0.0001	<0.0001	<0.0001
12	rs237462	47,466,610	intron	0.0019	0.0035	0.0021
13	rs237476	47,484,789	intron	0.0052	0.0102	0.0076
14	rs742758	47,495,219	intron	<0.0001	<0.0001	<0.0001
15	rs572845	47,510,021	intron	0.0027	0.0022	0.0007
First principal component				<0.0001	<0.0001	<0.0001

ISSN: 1753-6561