Evaluation of pooled association tests for rare variant identification

BMC Proceedings

Table 1 Type I error rates (results based on analyzing Q4)

Significance level	T1	T5	WS	VT
Without adjustment for any covariate
α = 0.05/3,205 = 1.56 × 10⁻⁵	0.00001	0.00002	0.00055	0.00053
α = 0.001	0.00086	0.00272	0.00861	0.00925
α = 0.005	0.00468	0.01055	0.02279	0.02384
α = 0.01	0.00922	0.01828	0.03454	0.03596
α = 0.05	0.04575	0.06324	0.09094	0.09546
α = 0.1	0.08971	0.10888	0.13954	0.14894
With adjustment for Age and Smoking status
α = 0.05/3,205 = 1.56 × 10⁻⁵	0.00001	0.00002	0.00001	0.00001
α = 0.001	0.00096	0.00094	0.00095	0.00095
α = 0.005	0.00473	0.00491	0.00485	0.00485
α = 0.01	0.00956	0.00973	0.00966	0.00972
α = 0.05	0.04918	0.05040	0.05037	0.04990
α = 0.1	0.09906	0.10148	0.10159	0.10087

ISSN: 1753-6561