Figure 3
From: Identity by descent and association analysis of dichotomous traits based on large pedigrees
Q-Q plots of three analyses using population data sets and family data sets. The panels display Q-Q plots of FDR-corrected gene-level p-values from all 200 replicates. Green dots are based on replicate 5. (a) Population-based case-control association studies, using the stratified analysis. (b) Family-based association analyses obtained by fitting logistic regression using the GEE. (c) Family-based IBD analyses, in which raw p-values of all rare and common variants are empirical p-values. These empirical p-values are based on 10,000 rounds of permutations.