Pathway-based joint effects analysis of rare genetic variants using Genetic Analysis Workshop 17 exon sequence data

Table 3 Association of rare SNPs in the VEGF pathway with traits in three databases

Trait	Database	Number of rare SNPs	Number of genes in GAW17 data set	Number of causal genes	P-value	Rank of significance
Q1	Reactome	53	5	5	1.77 × 10⁻¹⁵*	1
	BioCarta	95	11	6	6.81 × 10⁻¹⁴*	2
	KEGG	66	17	2	1.83 × 10⁻⁷*	11
Disease	Reactome	53	5	0	4.95 × 10⁻⁵*	3
	BioCarta	95	11	3	4.69×10⁻⁵*	2
	KEGG	66	17	5	2.17×10⁻⁴	4

ISSN: 1753-6561