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The prevalence of metabolic syndrome up to 5 years post-partum in patients with a history of gestational diabetes mellitus
© Crowe et al; licensee BioMed Central Ltd. 2012
- Published: 9 July 2012
- Public Health
- Diabetes Mellitus
- Insulin Resistance
Metabolic syndrome (MetS) is associated with cardiovascular mortality and increased risk of type 2 diabetes.
We examine the prevalence of MetS in a cohort of Caucasian women with previous gestational diabetes (GDM) (n=116), and those with normal glucose tolerance (NGT) during pregnancy (n=51). Fasting glucose alone (known DM/pre-diabetes post-partum patients) or 75g OGTT (other patients), lipid profile, insulin and c-peptide were performed. We calculated insulin resistance using the HOMA2-IR computer model.
Number with MetS (ATPIII criteria) (%)
Mean HOMA-2IR (+/- SD)
Number with HOMA-2IR>1.7 (%)
DM/pre-diabetes post GDM (n=33)
NGT post GDM (n= 83)
No history GDM (n=52)
Metabolic syndrome and insulin resistance are significantly more prevalent in Caucasian patients with GDM progressing to post-partum DM/pre-diabetes than those who do not (p<0.01), suggesting a need to target lifestyle changes in the early post-partum period to help prevent progression to T2DM.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.