Table 3 List of loci with most significant epistasis signals for real and simulated phenotypes
Phenotype | Locus 1 | Locus 2 | p Value |
|---|---|---|---|
Real phenotypes | |||
DBP | INS (rs5506) | PIK3R2 (rs1011320) | 0.0002169 |
SBP | INSR (rs3745548) | PRKCG (rs3745405) | 0.0002839 |
MAP | INSR (rs3745548) | PRKCG (rs3745405) | 0.0001629 |
PP | PIK3CD (rs28730674) | PIK3R1 (rs61749601) | 0.0000746 |
Hypertension | PIK3CD (rs11121484) | ATP1B2 (rs1642763) | 0.0004479 |
Simulated phenotypes | |||
DBP | PIK3R1 (rs3730089) | INSR (rs78312382) | 0.0001178 |
SBP | INSR (rs6413502) | INSR (rs3815902) | 0.0000232 |
MAP | INSR (rs6413502) | INSR (rs3815902) | 0.0002596 |
PP | PIK3R3 (rs75775922) | PIK3CA (rs3729682) | 0.0001188 |
Hypertension | INSR (rs2860177) | INSR (rs7252268) | 0.0004135 |